|
Vaginal candidiasis
[ detailed analysis & information ]
Vaginal candidiasis is a fungal or yeast infection of
the vulva and/or vagina. It causes a smelly, thick, white-yellow discharge
that might be accompanied by itching, burning and swelling. It can also
can make walking, urinating or sex very painful.
Vaginal candidiasis can be an occasional problem for even the healthiest
woman. However, it's more common and severe in women with weakened immune
systems. For many, a repeating or worsening vaginal yeast infection is the
first symptom of HIV infection. This infection can occur at any CD4+ cell
count but is likely to occur more often when your CD4+ count falls below
100.
Go
Top
Cause
Vaginal candidiasis is caused by the fungus called
Candida. Everyone has small quantities of the fungus in the mouth, vagina,
digestive tract and skin. In healthy persons, "friendly"
bacteria and the immune system prevent the fungus from causing infection.
However, if you have a damaged or weakened immune system, it's easier for
Candida to grow and cause disease.
Certain drugs can alter the natural organisms in the vagina, which can
then promote the growth of Candida. These include the extended use of
antibiotics, steroids and oral contraceptives (birth control) with a high
estrogen content. Other factors that may cause candidiasis include:
diabetes, pregnancy, using antihistamines (drugs commonly used to prevent
allergies and rash) and iron, folate, vitamin B12 or zinc deficiency.
Factors that may weaken the immune system—from cancer chemotherapy to
stress and depression—can also cause candidiasis. Tight fitting pants
and reactions to chemical ingredients found in soaps and detergents can
lead to vaginal candidiasis as well.
Go
Top
Diagnosis
Vaginal candidiasis is usually diagnosed by appearance
and symptoms. Because symptoms are similar to many other conditions, like
the sexually transmitted disease trichomonas, your doctor should confirm a
diagnosis by scraping an affected area for examination under a microscope.
Other lab tests are usually done if the infection does not clear up after
treatment.
Go
Top
Treatment
Topical treatments (active only on the area where
applied) are the first choices for yeast infections and these generally
work for mild-to-moderate cases. These include vaginal creams,
suppositories or tablets. Many are available over-the-counter in a
drugstore.
Most topical treatments are put into the vagina once or twice a day for
three days or once a day for seven days. (See table for drug names and
doses). Longer courses (7-14 days) may be more effective in HIV-positive
women.
Generally, topical treatments do not cause side effects, but in a small
number of women they may lead to vaginal burning, itching or skin rash. A
few women have experienced cramps or headaches. Oil-based vaginal creams
should be used with caution as they may weaken latex condoms and
diaphragms (see chart).
If topical treatment does not work, or if outbreaks recur often, you may
need systemic (throughout the body) drugs. A single oral dose of
fluconazole (Diflucan) is increasingly used to treat vaginal candidiasis
Go
Top
Treating Vaginal Candidiasis
| Drug Name |
Dose |
Notes |
| Topical Therapies |
|
|
| Butoconazole 2% cream |
5 grams for 3 days |
Available over-the-counter. May weaken latex condoms
and diaphragms. |
| Clotrimazole (Lotrimin) 1% cream |
5 grams for 7-14 days |
Available over-the-counter. May weaken latex condoms
and diaphragms. |
| Clotrimazole (Mycelex) 100mg vaginal tablet |
One 100mg tablet for 7 days or two 100mg tablets for
3 days |
|
| Clotrimazole (Mycelex) 500mg vaginal tablet |
Single dose |
|
| Miconazole (Monistat) 2% cream |
5 grams for 7 days |
Available over-the-counter. May weaken latex condoms
and diaphragms. |
| Miconazole (Monistat) 200mg vaginal suppository |
Once a day for 3 days |
Available over-the-counter. |
| Miconazole (Monistat) 100mg vaginal suppository |
Once a day for 7 days |
Available over-the-counter. |
| Miconazole (Monistat) 1,200mg vaginal suppository |
Single dose |
|
| Tioconazole (Vagistat) 300mg ointment |
A single dose |
Available over-the-counter. |
| Terconazole (Terazol 7) 0.4% cream |
5 grams for 7 days |
May weaken latex condoms and diaphragms. |
| Terconazole (Terazol 3) 0.8% cream |
5 grams for 3 days |
May weaken latex condoms and diaphragms. |
| Terconazole (Terazol 3) 80mg vaginal suppository |
Once a day for 3 days |
|
| Oral Therapies |
|
|
| Fluconazole (Diflucan) |
One 150mg dose |
Not recommended for pregnant women; sometimes used
weekly as a preventive measure. |
| Other Therapies |
|
|
| Nystatin vaginal tablet (Mycostatin) |
Applied to affected areas twice a day for three
days. |
Available over-the-counter. May be useful for
recurrent infections (apply every 7 days for 1 month); messy
application; can cause vaginal swelling; refraining from sex or
use of condom recommended |
Go
Top
Preventing Vaginal Candidiasis
There are many practical ways to try to prevent vaginal candiaisis (see below). For women with recurrent vaginal candidiasis, a single dose of fluconazole weekly is sometimes used to prevent the infection. Caution is recommended when considering this approach since extended use of fluconazole can result in candidiasis that becomes resistant to treatment.
Gentian violet has been used to treat and prevent fungal infections for years. It is available without a prescription, but your doctor may have special instructions for preventing vaginal candidiasis. As a prevention strategy, it is applied onto the affected areas with a cotton swab once a week for four weeks, or as instructed by your doctor.
Go
Top
Treating and Preventing Fungal Infections Naturally
There's a strong connection between what you eat and the health of your immune system. Nevertheless, nutritional approaches to prevent and treat conditions like candidiasis are complicated and controversial. While there isn't a magic recipe that prevents or treats yeast infections in everyone, following some basic guidelines may lower the risk of yeast becoming a problem for you.
Sugar, yeast, dairy, wheat, caffeine, nicotine and alcohol promote the growth of yeast. Nutritionists recommend ingesting as little as possible of these foods and products to decrease the risk and/or severity of yeast infections. Eating larger amounts of foods that may suppress the growth of yeast, like garlic or milk and yogurt that contain acidophilus, may help prevent yeast infections or provide extra treatment for infections that occur.
Go
Top
Practical Prevention Tips
 |
Avoid douching. Douching changes the normal acid
level of the vagina and causes inflammation, both of which may
increase the risk of infection. |
 |
Try not to use scented laundry soap, bleach or
fabric softeners. Chemicals in scented laundry soap can cause yeast
infections. Bleach in your clothes may harm the friendly bacteria
that stop Candida from taking over. Also, fabric softeners
stop moisture from escaping, keeping the skin damp and more likely
for yeast to grow. |
 |
Avoid tight clothes which block air flow. |
 |
Wear cotton underwear as it lets air in and
moisture out. |
 |
Avoid washing the vaginal area with deodorant,
scented soaps or bubble baths. |
 |
Try a non-soap cleanser that is less likely to
irritate the vaginal area if yeast infections are a problem for you. |
Go
Top
Food as Prevention
 |
Decrease or avoid sugars (corn and maple syrup,
glucose, fructose and sucrose). Sugars are food for Candida
and help it grow. |
 |
Decrease or avoid alcohol. Alcohol converts to
sugar and helps Candida grow. |
 |
Swallow large amounts of garlic. (Fresh is
considered best—mince and put into empty gelatin capsules, up to
six cloves a day.) Garlic is believed to have some natural
anti-fungal properties. (Note: it is unknown if large amounts of
garlic interfere with anti-HIV drugs, but some evidence exists that
it may increase the risk of side effects from ritonavir [Norvir].) |
 |
Drink milk or eat yogurt that contains
acidophilus bacteria. Acidophilus is "friendly" bacteria
that helps keep your body in balance. |
Go
Top
Anti-fungal Drugs and Pregnancy
The US Public Health Service Guidelines for the Prevention of Opportunistic Infections include recommendations about using anti-fungal drugs during pregnancy. In short, the Guidelines recommend that oral azole anti-fungals—including fluconazole (Diflucan), itraconazole (Sporanox) and ketoconazole (Nizoral)—should not be used during pregnancy because they have caused birth defects in animal studies.
If you are pregnant and treating or preventing vaginal candidiasis, topical therapies are preferable. Moreover, it's recommended that oral azole drugs be stopped in women who become pregnant and that women taking these drugs use effective birth control.
Go
Top
Conclusions
Candidiasis is among the most common conditions in people with HIV. While it's a relatively common condition in general, it's often the first sign of illness that HIV disease is progressing to a more severe stage, particularly yeast infections that recur or respond less to treatment. Candidiasis outbreaks can be frequent, cause great discomfort and add to the decline in health seen in AIDS.
It's important for you to prevent and treat vaginal candidiasis, like other forms of candidiasis. This will improve the discomfort created by the infection and reduce further damage candidiasis may cause to your immune system.
|