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The WHO defines "Essential drugs as those which
satisfy the health care needs of the majority of the population;
they should therefore be available at all times in adequate amounts
and in the appropriate dosage forms."
The goal for health for all has been approached
in many countries through strengthening of primary health care.
Providing this network of dispensaries with regular supplies of
quality drugs to treat the most common health conditions is perhaps
the most important factor, which boosts the confidence of the
population in the health care delivery system.
It is not a simple matter to ensure the
availability of safe, affordable essential drugs. Legislations,
technical and medical logistic skills of an advanced nature are
needed for ensuring supplies. Pharmaceutical companies market their
products with little concern for the different health needs or
priorities of a country and they fuel demand by manufacturing and
selling non-essential drugs like latest antibiotics, tranquilizers,
tonics most with no proven therapeutic value.
Developing countries cannot afford to waste
their resources on the luxury of non-essential drugs Pharmaceutical
companies perceive the vast potential of these countries in terms of
the sheer size of the population and laxity of rules. These
countries are therefore considered ideal for selling their high
priced, non-essential formulations with a consequent burden on the
individual.
In the interest of social justice and health,
out of which the concept of essential drugs was born, it is time
that the principle is adopted by all developing countries. They
should draw up their priorities, develop national drug policies and
thus ensure access of quality medicines to all.
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STDs are a public health problem, Reproductive
Tract Infections are compounded by complications of STD and can
result in primary and secondary infertility, poor pregnancy outcomes
such as abortions, pre-terry delivery, malformations and congenital
STDS. In addition these diseases can cause stress and marital
problems.
While studies have been done to find out the
extent of the problem, these cannot describe the personal anguish
and harm that such diseases can cause to women. These research
findings urgently need to be translated into policy and used to
raise awareness about these diseases among women and men. Most women
diagnosed with an STD are symptomless they only find out they are
infected when tested at a clinic for another reason usually for
ante-natal and family planning services. This fact is emphasized by
a study in which women from twelve different African countries
attending ante-natal clinics were screened for STDs and were found
to have syphilis at rates varying from 2-33%. The effect of STDs on
pregnancy associated conditions is severe. STD infection while
pregnant can lead to stillbirth, pre-mature birth, post partum
pelvic inflammatory disease, eye impairment in the new-born and
perinatal AIDS.
In order to deal with the serious problem of
STDs in pregnant women it is important to at least carry out
syphilis screening at ante-natal clinics and provide prompt
treatment to protect the mother, baby and the sexual partner(s).
STDs have a negative effect on women's fertility although the actual
number of women who become infertile due to STDs is not known.
Female commercial sex workers are even more at risk of contracting
STDs than other women. This is because they have multiple sexual
partners and condom use is low.
The high rate of various types of infections
among CSW cannot be over-emphasised because these workers are part
of society and interact with the male population, locally,
nationally and internationally. During this decade research on
relationship and other STDs has revealed that sexual transmission of
HIV may be facilitated by the presence of STDS, this may partly be
an explanation of varying HIV rates around the world. HIV infection
and consequent immunodeficiency may alter the progress of the
disease, diagnosis or response to other STD treatment. STDs may
influence the natural progression of HIV by accelerating the
progression of clinical disease. HIV infection may also increase the
susceptibility to other STDs.
In India according to a baseline study conducted
in l992,in a red light area in Calcutta 59% of the CSWs were found
to have STDs. In Madras the VDRL positivity was as high as 10% in
female remand prisoners and the rate among women attending antenatal
clinics 1.74%. In a population based cross-sectional study in rural
Maharashtra 92% of all women surveyed were found to have one or more
gynaecological problems. Infections of the genital tract (vaginitis
cervicitis and PID) contributed to half of thin morbidity.
The fundamental goal of STD control programmes
is early detection and treatment of the disease preferably at the
point of patient's first contact with the health system. The
syndrome approach to STD case management uses common symptom complex
of STD as a starting point and to treat and counsel about STD
prevention and partner notification. Condom provision is an
essential part of syndromic management. Besides being simple and
inexpensive syndromic case management allows for diagnosis and
treatment in a single visit. Standardisation of treatment regimens
is of paramount importance as they facilitate training and
supervision, delay the development of antimicrobial resistance in
sexually transmitted agents such as N.gonorrhoez and H. ducreyi and
most importantly, rationalise the procurement of drugs.
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The chart below gives the
treatment path for Genital Ulcers: |
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TREATMENT REGIMENS: |
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Syphilis
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Chancroid |
Benzathine penicillin, 2.4
million units i.m. after a proper sensitivity test OR
Tetracycline 500 mg orally 4 times a day x 15 days OR
Doxycycline 100 mg orally twice daily x 15 days OR Erythromycin
500 mg orally four times a day x 15 days |
Erythromycin 500 mg orally four
times a day x 7 days. OR Ciprofloxacin 500 mg single oral dose
OR Ceftrioxone 200 mg single i.m. dose OR Spectinomycin 2g
single i.m. dose OR Co-trimoxazole Double Strength Orally twice
daily x 7 days |
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Herpes |
Primary Genital
Herpes |
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No known cure. Course of symptoms can be
modified if diagnosed early and promptly treated with
acyclovcir.
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Acyclovir 200 mg orally 5 times a day x 7 days
Recurrences: Advise to keep genital area clean by using saline
washes, counsel and reassure about recurring lesions. Analgesics can
be given for severe
pain. |
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Most
commonly caused by vaginitis but may also be the result of
cervicitis. Common Causative organisms are N.gonorrhoeae and C.
trachomatis(cervicitis),Trichomonas vaginalis, Candida albicans and
synergistic combination of Gardnerella vaginalis and bacteria
(vaginitis) Clinical differentiation between the two conditions is
difficult.
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Treatment of vaginitis |
Metronidazole 2g single oral dose under
supervision or Metronidazole 400 mg given orally twice daily for 7
days plus NYSTATIN 100,000 units (one pessary) inserted
intravaginally daily at night for l4 days or MICONAZOLE or
CLOTRIMAZOLE 200 mg may be inserted into vagina daily for 3 days. or
CLOTRIMAZOLE 500 mg is inserted into vagina once daily. Patient is
advised to take the treatment and return in 14 days.
If the symptoms persist treat for cervicitis as
follows:
CIPROFLOXACIN 500 mg in a single oral dose
(under supervision) or NORFLOXACIN 800 mg single dose or CEFIXIME
400 single dose. CEFTRIAXONE 250 single IM dose or SPECTINOMYCIN in
2 gs in IM Dose Plus DOXYCYCLINE 100 mg orally twice daily for 7- 14
days for chlamdial infection or TETRACYCLINE 500 mg orally 4 times a
day for 7 days or ERYTHROMYCIN 500 mg orally 4 times a day for 7
days.
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LAP is often the presenting feature of women
with pelvic inflammatory disease(PID) which is an infection of
female genital tract above the internal os of the cervix and
therefore means endometritis, salpingitis, tubo ovarian abscess and
pelvic peritonitis. PID occurs as a result of ascending infection
from the cervix and is caused by N. gonorrhoeae, C.trachomatis and
anaerobic bacteria. The seriousness of PID lies in the fact that it
can lead to pelvic peritonitis ovarian abscess and to generalised
peritonitis which can be fatal illness. Blocked fallopian tubes
following salpingitis could lead to subfertility or
infertility.
Treatment: Remember that, in treating PID, treat
simultaneously for gonococcal, chiamydial and anaerobic bacterial
infections.
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Treatment for
Gonorrhea |
CIPROFLOXACIN 500 mg single oral dose
OR NORFLOXACIN 800Mgsingleoraidose OR CEFXIME 400 mg single
oral dose OR CEFTRIAXONE 250 mg single oral dose SPECTINOMYCIN 2
g single IM dose
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PLUS Treatment for
chlamydial infection |
DOXYCYCLINE 100 mg orally twice daily for
14 days OR TETRACYCLINE 500 mg orally four times daily for 14
days OR ERYTHROMYCIN 500 mg orally four times daily for 10
days.
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PLUS Treatment for anaerobic
bacterial infection |
METRONIDAZOLE 400 mg given orally twice daily for 14
days.
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Inguinal Bubo is acute suppurative
inguinal lymphadenitis presenting as a painful swelling. A bubo can
result from any kind of acute infection of the skin on the pubic
area, genitals, buttocks, anus, thighs, legs, feet or toes. It may
occur in STD such as chancroid and lymphogranuloma venerum(LGV). The
enlarged inguinal lymph nodes, that are found in syphilis and HIV
infection are not painful or tender to palpation and therefore can
not be really be considered as bubos.
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Treatment |
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If you find an inguinal bubo but no genital
ulcer, treat the patient for LGV. A history of transient superficial
ulcer is consistent with diagnosis of LGV. The treatment consists of
Tetracycline 500 mg qid for 14 days. Alternatively Erythromycin 500
mg orally 4 times daily for 14 days.
A fluctuant bubo should be aspirated with a wide
bore needle and syringe every second or third day until there is no
aspirate. Under no circumstances should a bubo be incised.
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One of the most unusual adverse reactions known
to be associated with fluroquinolone antibiotics is the occurrence
of tendinitis. This is a serious effect since it may progress to
tendon rupture with resultant disability. Over 2OO cases have been
reported in the literature with the majority from France. Most
members of the class including ciprofloxacin, enoxacin, ofloxacin,
and norfloxacin have been implicated. The Achilles tendon is most
often involved.
Adverse Drug Reactions Advisory Committee
(ADRAC) of Australia has recorded 25 reports of tendinitis in
association with norfloxacin. Most (22) have been with ciprofloxacin
and the other three with norfloxacin. The majority of the patients
involved were elderly. The daily dose of ciprofloxacin ranged from
750 mg to 2250 mg and for norfloxacin the usual daily dose of 800
mg. The average time of onset of reaction was within the first week.
Almost all (23) of the reports specified Achilles tendon as the site
of tendinitis. A number of risk factors have been identified with
regard to this adverse reaction; these include age, renal
dysfunction and concommitant corticosteroid therapy. Prescribers are
reminded that tendinitis especially involving the Achilles tendon,
is a rare adverse effect of the Fluoroquinolones. It is more likely
to occur in association with the risk factors referred to above. The
antibiotic should be withdrawn immediately to reduce the risk of
tendon rupture.
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The role of any National Drug Policy is
io use available resources to develop pharmaceutical services to
meet the requirements of its citizens in prevention, diagnosis and
treatment of diseases using efficacious high quality safe
cost-effective pharmaceutical products. A National Drug Policy shall
serve as the guide document for human resource planning and
management.
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- To ensure constant availability of safe and
effective drugs to all sectors of population.
- To provide drugs through the Government, private
and Non-Government sectors at affordable prices.
- To facilitate Rational Drug Use through sound
prescribing, good dispensing practices and appropriate usage.
- To ensure that the quality of drugs manufactured
or imported into a country meet internationally accepted quality
standards.
- To encourage self sufficiency through local
manufacture of, drugs for consumption and export.
(Source: WHO, DAP
and WOMEN HEALTH ACTION FOUNDATION PUBLICATIONS)
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